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Updated: May 23, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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由各种小分子抗剂对CXCR4进行调制的基础结构机制

Xiaohong Sang1, Haizhan Jiao2, Qian Meng3

  • 1Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.

Proceedings of the National Academy of Sciences of the United States of America
|March 10, 2025
PubMed
概括

对CXCR4 (CXC化学受体类型4) 的结构洞察力揭示了小分子抗剂如plerixafor和 mavorixafor是如何结合的. 这些发现有助于开发针对艾滋病毒和其他疾病的新型CXCR4向疗法.

关键词:
在CXCR4中,CXCR4是最常见的.G蛋白结合受体的受体是什么化学因子受体的化学因子受体化-EM结构的结构.小分子对手的小分子对手.

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