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Updated: May 23, 2025

Laser Micro-Irradiation to Study DNA Recruitment During S Phase
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计算模型确定了DNA损伤和氧化应激反应之间的交叉通话的主要媒介

Elsje J Burgers1, Raju P Sharma1, Carl Joshua S Eugenio1

  • 1Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

PLoS computational biology
|March 10, 2025
PubMed
概括

开发了计算模型,以了解氧化应激反应 (OSR) 和DNA损伤反应 (DDR) 途径在肝细胞中如何相互作用. 模型揭示了关键的交叉点,特别是p21对OSR路径的重大影响.

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