通过计算流体动力学模拟,评估术后慢性鼻炎患者的雾化和鼻水效率
Oveis Pourmehran1, Alkis Psaltis1, Sarah Vreugde1
1Department of Surgery-Otolaryngology Head and Neck Surgery, Adelaide Medical School, The University of Adelaide, Adelaide 5011, Australia.
Computer methods and programs in biomedicine
|March 10, 2025
概括
计算流体动力学 (CFD) 模拟与功能内镜鼻手术 (FESS) 后药物输送的雾化和鼻灌进行了比较. 雾化改善了某些鼻的沉积,而灌对额头鼻更有效,突出了针对手术后策略的需要.
科学领域:
- 生物医学工程 生物医学工程
- 计算流体动力学 (CFD) 是一种计算流体动力学.
- 鼻科 鼻科是指鼻科的专家.
背景情况:
- 慢性鼻炎 (CRS) 是一种影响生活质量的常见疾病.
- 功能性内镜外科手术 (FESS) 是当医疗治疗失败时的一种治疗选择.
- 有效的术后药物输送对于成功的FESS结果至关重要.
研究的目的:
- 在使用CFD的FESS后鼻腔模型中,将雾化与鼻灌的药物递送效率进行比较.
- 评估解剖学变化的影响药物沉积在鼻上.
主要方法:
- 从CT扫描中生成了八个FESS后模型,其中包括骨骨的大小变化和中间轮切除术.
- 使用3D Slicer®进行图像细分,使用Ansys SpaceClaim®进行几何准备.
- 进行了CFD模拟,以分析雾化和鼻灌的药物输送效率.
主要成果:
- 雾化显示,随着手术修改,大腔和状鼻的药物沉积得到改善.
- 鼻腔灌显示了更高的药物输送效率到额头鼻腔.
- 灌后的剩余液体层显著影响了对比方法的评估.
结论:
- 药物输送策略应适应FESS后的个体手术和解剖因素.
- 量身定制的术后方案可以潜在地提高CRS治疗结果,提高患者的遵从性,并减少复发.
- 需要进一步的研究来量化残留液体层厚度及其对药物保留的影响.
相关概念视频
Suctioning the Nasopharyngeal Airway
236
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
236
Administering Oxygen by Nasal Cannula
306
Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
306
Epistaxis
115
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
115
Acute Respiratory Failure-V
113
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
113
Mechanical Ventilation III: Noninvasive Ventilation
68
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
68


