和多醇基物质和老年人2型糖尿病:综合跨区域人口研究和元分析
Mengyi Wang1, Zhu Wang1, Yan Liu1
1State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China.
International journal of hygiene and environmental health
|March 10, 2025
概括
暴露于per-和多醇基物质 (PFAS) 可能对老年人2型糖尿病 (T2D) 风险产生反向影响. 需要进一步的研究来了解PFAS.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 和多基基物质 (PFAS) 是广泛存在的环境污染物.
- PFAS暴露与葡萄糖代谢障碍,包括2型糖尿病 (T2D) 之间的关联尚未完全理解.
- 老年人可能特别容易受到环境暴露的代谢影响.
研究的目的:
- 调查暴露于单个和混合PFAS对老年人葡萄糖代谢障碍的影响.
- 在中国老年人群中评估与各种PFAS相关的T2D风险.
- 通过对现有文献进行元分析来验证发现.
主要方法:
- 一项涉及704名来自中国武汉的老年人 (年龄>65岁) 的横截面研究.
- 使用液体染色学-质谱学量化血中12种PFAS的量化.
- 使用通用线性模型和基于量子的g计算进行统计分析,并通过元分析进行补充.
主要成果:
- 在所有12个测量的PFAS中,检测率高 (>80%).
- 观察到某些PFAS (例如PFDoA,PFUdA,PFDA,PFNA,PFOA) 与T2D风险或禁食葡萄糖受损之间存在不良关联.
- 分析证实了PFDA和PFUdA与T2D风险的反向关联,以及PFOA的反向U形关系.
结论:
- PFAS暴露可能与T2D风险和老年人禁食葡萄糖受损相反相关.
- PFDA和PFUdA显示出一致的反向关联,而PFOA显示出非线性剂量反应关系.
- 进一步调查PFAS介导的代谢作用的生物机制对于准确的风险评估至关重要.
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