在儿童恶性瘤治疗后,肥胖的发展
Elpis Athina Vlachopapadopoulou1
1Department of Endocrinology-Growth and Development, Children's Hospital "P. & A. Kyriakou", Athens, Greece.
Hormone research in paediatrics
|March 10, 2025
概括
儿童癌症幸存者 (CCS) 由于治疗因素和诊断特征而面临更高的肥胖风险. 早期监测和生活方式咨询对于预防这些人肥胖和代谢综合征至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 肥胖是一种复杂的疾病,受多种因素的影响,包括遗传和环境.
- 儿童癌症幸存者 (CCS) 患肥胖和相关并发症的风险增加,这是癌症治疗的长期影响.
- 了解CCS中肥胖的特定风险因素对于及时干预至关重要.
研究的目的:
- 审查流行病学数据,病理生理学和CCS中肥胖发展的危险因素.
- 确定潜在的调解者,有助于增加该人口的BMI.
- 巩固CCS中关于肥胖的知识,以改善临床管理.
主要方法:
- 对流行病学数据,病理生理学和风险因素的文献综述.
- 分析导致BMI增加的机制,例如下丘脑功能障碍和皮质类固醇治疗.
- 将风险因素分为与诊断相关的和独立的因素.
主要成果:
- 诊断时体重指数增加,年龄较小 (<6岁),部辐射,下丘脑-垂体区域瘤/手术,膜瘤和德克萨米他治疗的CCS中超重/肥胖的风险更高.
- 对儿童恶性瘤进行治疗的CCS有很高的发展代谢综合征的可能性.
- 具体的风险因素包括治疗方式和独立因素,如性别,年龄,种族,社会经济地位和初始BMI.
结论:
- 肥胖是儿童癌症治疗的重要长期后果之一.
- CCS需要定期监测身高,体重和BMI.
- 每年就身体活动和饮食进行咨询对于预防CCS中肥胖和相关慢性疾病至关重要.
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