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银改性细菌纤维素的绿色合成,具有增强的抗菌活性,用于先进的生物医学应用

Subarna Sandhani Dey¹, Md Sahadat Hossain², Rajib Sarkar¹

¹Food Microbiology Research Laboratory, Institute of Food Science and Technology (IFST), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.

International journal of biological macromolecules

|March 10, 2025

概括

生物合成的细菌纤维素 (BC) 用银纳米粒子 (Ag NPs) 增强,具有强大的抗菌活性. 这种新型的合银的BC (BC_Ag) 显示出生物医学应用的巨大潜力,特别是在伤口愈合方面.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
微生物学微生物学

背景情况:

细菌纤维素 (BC) 是一种多功能生物聚合物,具有潜在的生物医学应用.
银纳米粒子 (AgNP) 具有显著的抗微生物特性.
将BC与AgNP结合起来可以创建先进的抗微生物生物材料.

研究的目的:

为了生物合成纯细菌纤维素 (BC).
使用环保的光催化还原方法,用银 (Ag) 浸BC,产生Ag-doped BC (BC_Ag).
为了评估合成的BC_Ag的抗微生物疗效和血红相容性,用于潜在的生物医学用途.

主要方法:

隔离了阿西托巴克特菌 sp. 用于BC生产的果.
环境友好型光催化还原用于在BC上浸Ag.
使用XRD,STA,FTIR,SEM和EDS进行BC_Ag的表征.
对各种致病性细菌和真菌 (Listeria monocytogenes,金黄色葡萄球菌,沙门氏菌,大肠杆菌, Pseudomonas aeruginosa,Candida albicans) 进行抗菌活性测试.
血液相容性的评估.

主要成果:

SEM和EDS证实了BC光纤网络上的银离子聚合,沉积与AgNO3度成比例.
即使在低度 (0.0001 M) 中,BC_Ag也表现出高血红相容性和针对测试病原体的显著抗菌活性.
在所有BC_Ag度中观察到20小时的完全病原体生长抑制,其中0.01MBC_Ag显示在潮湿条件下超过100小时的特定病原体的抑制.

结论:

合成的银的细菌纤维素 (BC_Ag) 具有广泛的,长期和持久的细菌静止和真菌静止活性.
这种材料显示出高血红相容性.
由于其强大的抗微生物特性,BC_Ag对未来在伤口愈合和其他生物医学领域的应用具有相当的希望.

关键词:

抗微生物活性的抗菌活性.细菌纤维素的细菌纤维素.生物聚合物的生物聚合物.长期的抑制长期的抑制银色的兴奋剂使用.

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