相关实验视频

Updated: May 23, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

从不同的乳腺癌试验中添加辅助药物

Timothée Olivier¹, Vinay Prasad²

¹Department of Oncology, Geneva University Hospital, 4 Gabrielle-Perret-Gentil Street, Geneva 1205, Switzerland; Department of Epidemiology and Biostatistics, University of California San Francisco, 550 16th St, 2nd Fl, San Francisco, CA 94158, USA.

Journal of cancer policy

|March 10, 2025

概括

对乳腺癌早期阶段的术后治疗方法的结合带来了挑战. 需要证据来确认组合治疗对单一治疗的益处和评估毒性,特别是在三阴性和激素受体阳性疾病中.

科学领域:

在瘤学瘤学.
临床试验临床试验
乳腺癌研究研究乳腺癌研究

背景情况:

早期可手术乳腺癌的外科手术治疗选择已经扩大.
同一个患者可能有多种治疗方法可用,这会给治疗选择带来挑战.
指导方针建议同时或连续使用治疗方法,但结合独立测试的策略可能是有问题的.

研究的目的:

突出结合术后治疗在早期乳腺癌中的困境.
质疑组合或连续疗法的净益处和毒性与第三阶段试验中的单一疗法.
倡导一种谨慎的,以证据为导向的方法和对组合试验的监管执法.

主要方法:

对涉及早期乳腺癌联合治疗的临床情景的审查.
分析组合药物的潜在好处和风险,如布罗利祖马布加奥拉帕里布或奥拉帕里布加CDK4/6抑制剂.
从单疗法数据推断到组合疗法疗效的讨论.

主要成果:

单独的疗法显示有效性,但在外科手术期间,联合/连续使用的净益在3期试验中未被证明.
潜在的没有额外的好处,如果同一组患者从每种疗法单独受益.
组合的短期和长期毒性尚未在第三阶段试验中进行评估,它们对剂量减少和整体结果的影响尚不清楚.

结论:

术后治疗的组合或连续使用需要谨慎的,基于证据的方法.
需要对组合试验进行监管执法,而不是从单一治疗数据中推断.
这种困境超越了乳腺癌,影响了各种癌症的新辅助和辅助疗法.

关键词:

一个辅助的辅助.乳腺癌 - 乳腺癌组合组合是一种组合.药物监管药物监管药物监管药品补偿金药品补偿金药品补偿金新辅助剂是一种新辅助剂.

更多相关视频

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: 5-HT₃ Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...