向着个性化的血压慢性治疗的方向
Germaine Cornelissen1, Yoshihiko Watanabe2, Larry A Beaty1
1Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA.
Biomedical journal
|March 10, 2025
概括
对抗高血压药物的最佳时间仍在争论中. 这项研究发现,根据昼夜血压模式,通过门诊血压监测分析药物管理的个性化,可以优化治疗的有效性.
科学领域:
- 时间生物学 时间生物学
- 药理学 药理学是指药理学的学科.
- 心血管医学 心血管医学
背景情况:
- 服用抗高血压药物的最佳时间尚未得到普遍同意.
- 药物对血压 (BP) 昼夜模式和个体患者反应的影响各不相同.
- 这种变化有助于治疗时间的持续争议.
研究的目的:
- 调查不同抗高血压药物给药时间对24小时血压概况的影响.
- 为了比较早晨和晚上的剂量对BP昼夜模式的影响.
- 探索患者对治疗时间的具体反应.
主要方法:
- 重新分析了从服用五种不同的抗高血压药物的患者获得的7天的门诊血压监测 (ABPM) 数据.
- 血压概况与醒来后1.5小时或每天两次服用药物的比较.
- 分析了从六个不同的给药时间接受洛萨坦/甲的患者获得的ABPM数据.
主要成果:
- 一些抗高血压药物改变了24小时的血压幅度,阶段或波形.
- 在一些患者中,晚上剂量改善了血压幅度,而在其他患者中,早上剂量是有效的.
- 在24小时血压节奏的所有特征中观察到显著的日复一日变化.
结论:
- 建议对抗高血压药物治疗时间进行个性化优化.
- 对多天ABPM数据的时代生物学分析可以指导个性化治疗策略.
- 将治疗时间与健康的昼夜血压模式相匹配,可能会提高治疗结果.
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