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Updated: May 23, 2025

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压力颗粒形成的抑制是突变p53所造成的脆弱性

Elizabeth Thoenen1, Atul Ranjan1, Alejandro Parrales1

  • 1Department of Pediatrics, Division of Hematology & Oncology, Children's Mercy Research Institute, Kansas City, MO, USA.

Nature communications
|March 11, 2025
PubMed
概括

肝细胞癌 (HCC) 中的突变p53 (mutp53) 通过抑制压力颗粒的形成,增强对索拉费尼布的敏感性. 这表明mutp53是ER诱导压力治疗的生物标志物.

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