相关实验视频

Updated: May 23, 2025

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

危急病患者的高IAP与AKI发病率增加有关:来自MIMIC-IV数据库的队列研究

ShengHui Miao¹, Mingkun Yang², Wen Li²

¹The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, 322000, China.

Scientific reports

|March 11, 2025

概括

16 mmHg以上的腹腔内压力 (IAP) 升高与危急患者急性损伤 (AKI) 风险增加有关. 更高的IAP也与更大需要持续置换疗法 (CRRT) 和增加28天死亡率相关.

科学领域:

关键护理医学关键护理医学
腎臟病學 (nephrology) 是一種醫學專業.
生理学生理学生理学

背景情况:

增加的腹腔内压力 (IAP) 可能会导致不良的生理影响.
IAP对重症患者功能的影响需要进一步研究.

研究的目的:

调查高IAP与急性损伤 (AKI) 发生率之间的关联.
探索IAP,连续脏替代疗法 (CRRT) 使用和危急病患者28天死亡率之间的关系.

主要方法:

利用MIMIC-IV数据库识别严重病患者,并进行IAP监测.
将患者分为低IAP和高IAP组 (IAP值 = 16 mmHg).
采用Cox比例危险回归和Kaplan-Meier分析来评估包括AKI,CRRT和死亡率在内的结果.

主要成果:

限制性立方线分析表明,在IAP较高的情况下,AKI的风险增加.
多变量分析显示,高IAP和AKI发病率之间存在显著的相关性 (HR:1.23).
高IAP组的AKI发病率更高,CRRT需求增加 (p=0.0028),28天死亡率更高 (p=0.001).

结论:

增加的腹腔内压力 (16 mmHg以上) 与重症患者中AKI的发病率较高显著相关.
升高的IAP与CRRT需求增加和28天死亡率更高有关.

关键词:

急性损伤是什么?急性损伤是什么?群组研究是一项群组研究.腹腔内压力在腹腔内压力这是一个MIMIC-IV数据库.

更多相关视频

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

相关概念视频

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...