英国生物银行数据表明,长期暴露在洪水中是发生痴呆症的危险因素
Yao Wu1, Rongbin Xu1, Danijela Gasevic1,2
1Climate, Air Quality Research (CARE) Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Communications medicine
|March 11, 2025
概括
暴露于洪水会增加痴呆症的风险,特别是在年轻人和妇女中. 这种风险在洪水发生的一年是最高的,并在六年内下降,突出显示了长期的健康影响.
科学领域:
- 环境流行病学环境流行病学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 洪水是全球最常见的自然灾害,影响了数十亿人.
- 洪水暴露对痴呆风险的长期影响尚不清楚.
研究的目的:
- 调查累积洪水暴露与患痴呆症的风险之间的关联.
- 探索洪水事件后基于年龄和性别的痴呆风险变化.
主要方法:
- 一个嵌套的病例控制研究,使用风险设置采样.
- 参与者每年累计遭受洪水影响的计算.
- 条件后勤回归模型来评估洪水和事件痴呆之间的关联.
主要成果:
- 痴呆的风险增加,阿尔茨海默病和血管痴呆与累积洪水暴露相关.
- 在暴露的一年观察到的风险最高,在六年内减少.
- 65岁以下的个人和女性在洪水后患痴呆症的风险不成比例地高.
结论:
- 提供了强有力的流行病学证据,将洪水暴露与痴呆风险增加联系起来.
- 突出了洪水等自然灾害对神经系统的长期影响.
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