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优化慢性病查策略 通过尿液测试条使用专蛋白-肌氨酸读取输出
Stijn Lambrecht1, Marijn Speeckaert2,3, Matthijs Oyaert4
1Department of Laboratory Medicine, Ghent University Hospital, C. Heymanslaan 10, Ghent, 9000, Belgium.
BMC nephrology
|March 11, 2025
概括
测试白蛋白与肌素比率 (ACR) 的尿液试卷有效地查低风险个体的慢性病 (CKD). 建议使用ACR,而不是蛋白质与肌素比率 (PCR),以使用测试条进行可靠的CKD查.
科学领域:
- 临床化学 临床化学
- 腎臟病學 (nephrology) 是一種醫學.
- 诊断查 诊断查 诊断查 诊断查
背景情况:
- 临床实验室对于诊断和监测慢性病 (CKD) 是至关重要的.
- 白蛋白尿是损伤的关键指标.
- 评估尿液试验带的性能对于选白蛋白尿症至关重要.
研究的目的:
- 为了评估质量和半量的白蛋白与肌素比率 (ACR) 和蛋白与肌素比率 (PCR) 试验条的有效性,用于白蛋白尿症查.
- 将ACR和PCR试卷的诊断性能与定量方法进行比较.
主要方法:
- 在横截面 (n=940) 和验证 (n=927) 患者队列中评估了ACR和PCR.
- 使用UC-3500仪器 (Sysmex) 进行了半定量性尿路ACR和PCR.
- 使用定量ACR和PCR作为参考标准来确定诊断性能.
主要成果:
- 半定量ACR在横截面队列中显示了78.1%的灵敏度和93.3%的特异性 (切断30 mg/g肌).
- 在验证队列中性能得到改善:灵敏度为89.9%,特异性为92.1%.
- 定性蛋白质度和半定量PCR显示敏感性较低 (分别为78.6%和69.8%).
结论:
- 尿液测试带的读数对于低风险人群中查CKD有价值.
- 专与肌素的比率 (ACR) 是通过尿液测试条进行CKD查的首选方法.
- 与PCR相比,ACR在检测白蛋白尿症方面提供了更高的性能.
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