在预测心血管疾病风险方面,胆固醇,高密度脂蛋白和葡萄糖指数与甘油三-葡萄糖指数相比:一项队列研究
Degang Mo1, Peng Zhang1, Miao Zhang1
1School of Medicine, Qingdao University, Qingdao, 266000, China.
Cardiovascular diabetology
|March 11, 2025
概括
胆固醇,高密度脂蛋白和葡萄糖 (CHG) 指数显示,与心血管疾病 (CVD) 风险增加有显著的线性相关性. 这一新型指数的预测能力与用于评估心血管疾病风险的已建立的三甘-葡萄糖 (TyG) 指数相当.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 是全球主要的健康负担.
- 胆固醇,高密度脂蛋白和葡萄糖 (CHG) 指数是代谢障碍的新标志物.
- 对于心血管疾病风险的CHG指数的预测值目前尚未研究.
研究的目的:
- 评估CHG指数对心血管疾病风险的预测效果.
- 为了将CHG指数的表现与已建立的甘油三-葡萄糖 (TyG) 指数进行比较.
- 评估成年人中CHG指数和心血管疾病风险之间的关系.
主要方法:
- 来自CHARLS数据库 (2011-2020) 的6249名45岁以上的成年人参与的队列研究.
- 计算CHG和TyG指数,在9年的随访期间追踪心血管疾病事件.
- 使用考克斯回归,限制立方线 (RCS) 和接收器运行特征 (ROC) 曲线进行分析.
主要成果:
- 1667名参与者 (26.68%) 患有心血管疾病.
- 在Cox回归模型中,CHG和TyG指数都与心血管疾病风险增加有关.
- CHG指数显示出正线性相关性,而TyG指数显示出与心血管疾病风险的非线性关系.
结论:
- 热血糖指数是心血管疾病风险增加的重要预测指标,显示出线性关联.
- 该CHG指数具有与TyG指数可比的预测性能,用于评估心血管疾病风险.
- CHG指数可以作为一种有价值的工具,用于识别心血管疾病风险较高的个人.
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