评估胰岛素抵抗轨迹对心血管疾病风险的影响,使用纵向目标最大概率估计
Yaning Feng1,2, Liangying Yin3, Haoran Huang4
1School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China. fengyaningCUHK@link.cuhk.edu.hk.
Cardiovascular diabetology
|March 11, 2025
概括
通过TyG-BMI和TyG指数测量的高和不断增加的胰岛素抵抗 (IR) 轨迹显著增加心血管疾病 (CVD) 风险. 早期识别这些IR模式可以帮助心血管疾病预防策略.
科学领域:
- 流行病学 流行病学
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 心血管疾病 (CVD) 与胰岛素抵抗 (IR) 密切相关.
- 关于红外线轨迹和心血管疾病发病率之间的纵向关系的研究有限,这解释了复杂的混因素.
- 本研究研究了IR轨迹对长期心血管疾病风险的动态影响.
研究的目的:
- 评估胰岛素抵抗 (IR) 轨迹对心血管疾病 (CVD) 风险的纵向影响.
- 利用先进的因果推理方法来分析IR的动态变化.
- 为了确定与心血管疾病发病率增加相关的特定IR轨迹.
主要方法:
- 来自中国健康与退休长度研究 (CHARLS) 队列的数据.
- 三甘油糖 (TyG) 指数和TyG体重指数 (TyG-BMI) 作为IR替代品.
- 纵向目标最大概率估计 (LTMLE) 评估红外线轨迹对心脏病风险的影响,调整为混因素.
主要成果:
- 确定了四个IR轨迹:低稳定,增加,减少和高稳定.
- 具有"高度稳定"和"增加"TyG-BMI/TyG指数轨迹的个体表现出显著更高的心血管疾病风险.
- "高稳定"的TyG-BMI组与"低稳定"组相比,心血管疾病的几率高出1694倍.
结论:
- 持续高或增加的IR,以TyG-BMI和TyG指数表示,与心血管疾病风险增加有关.
- 与TyG指数相比,TyG-BMI对心血管疾病风险的赔率比率始终高.
- 早期检测红外线轨迹有助于积极预防心血管疾病.
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