百万级数据的双向门德尔随机化和调解分析揭示了甲状腺相关的表型,吸烟和肺癌之间的因果关系
Xiang Wang1,2,3, Xuan Wang1, Mengsheng Zhao1
1Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Journal of biomedical research
|March 11, 2025
概括
甲状腺功能障碍,包括甲状腺功能障碍和甲状腺功能障碍,因果上会增加肺癌的风险,特别是在吸烟者中. 自由甲状腺素 (FT4) 水平显示出保护作用,甲状腺功能障碍症介导吸烟.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传流行病学遗传流行病学
背景情况:
- 甲状腺激素会影响各种细胞过程,但它们在肺癌发育中的作用仍然存在争议,并未得到充分研究.
- 目前对甲状腺功能和肺癌发生的研究是有限的,需要进一步调查潜在的因果关系.
研究的目的:
- 使用孟德尔随机化 (MR) 调查甲状腺功能障碍 (甲状腺功能低下,甲状腺功能过高) 和肺癌风险之间的因果关系.
- 探索甲状腺表型在吸烟行为和肺癌之间的关联中扮演的调解角色.
- 评估自由甲状腺素 (FT4) 和正常范围的甲状腺刺激激素 (TSH) 对肺癌风险的影响.
主要方法:
- 使用英国生物库数据进行双向孟德尔随机化 (MR) 分析.
- 分层式MR分析以评估吸烟行为子组中的调解效应.
- 利用与甲状腺功能和肺癌相关的遗传变异进行因果推断.
主要成果:
- 肺癌风险与甲状腺功能低下症 (HR=1.14) 和甲状腺功能增强症 (HR=1.55) 之间确实存在显著关联.
- 核磁共振分析表明甲状腺功能低下症 (OR=1.09) 和甲状腺功能增强症 (OR=1.08) 对肺癌风险的因果关系.
- 升高的自由甲状腺素 (FT4) 水平表明对肺癌有保护作用 (OR=0.93).
- 甲状腺功能障碍对肺癌风险产生因果影响,特别是在吸烟者中,甲状腺功能过高介于吸烟开始年龄的影响.
结论:
- 甲状腺功能障碍,包括甲状腺功能低下和甲状腺功能过高,在肺癌的发展中起着因果作用.
- 这些甲状腺疾病仅仅影响吸烟者肺癌风险.
- 甲状腺功能障碍的表型在将吸烟行为与肺癌联系起来的途径中起着重要的调解作用.
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