剥夺对皮层发育和青少年精神病症状的影响
Megan Thomas1,2, Sarah Whittle1,2, Vanessa Cropley1,2
1Orygen, Parkville, Victoria, Australia.
概括
早期生活中的剥夺与青春期的精神病类似经历 (PLEs) 有关. 这种关联部分可以通过在发育过程中皮质体积和结构的变化来解释.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 早期生活中的剥夺增加了精神病症状的风险.
- 连接剥夺和精神病的潜在机制尚未完全理解.
- 皮层发育是一个潜在的调解因素.
研究的目的:
- 检查各种形式的早期生活剥夺与青少年精神病类似经历 (PLEs) 之间的关联.
- 调查皮层体积变化是否调解这些关联.
- 为了探索性别特异性的影响.
主要方法:
- 从青少年大脑认知发展研究中分析了6323名年轻人.
- 在9-11岁时评估总体,物质,人际,认知和社区剥夺.
- 两年后,对类似精神病的经历 (PLEs) 的检查.
- 使用基线皮质体积及其变化速率进行中介分析.
主要成果:
- 所有的剥夺措施都与PLE的增加有关.
- 皮层结构的变化部分调解了这些关联.
- 观察到视觉和感觉运动区域的下基线皮质体积.
- 协会区域的皮层体积下降更为急剧,特别是在女性身上.
结论:
- 早期的剥夺可能会通过皮质结构的破坏导致类似精神病的经历.
- 这种联系在多种剥夺类型中是一致的.
- 与剥夺相关的皮质变化持续到青春期早期.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
43
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
43
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
353
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
353
Biological Causes of Schizophrenia
29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29
Depressive Disorders: Etiology
26
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
26
Cognitive Development During Adolescence
38
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
38
Revisionist Views of Adolescent and Adult Cognition
22
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
22


