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鉴定Lamiophlomis rotata中的活性成分,可以增加小鼠皮肤中的伤口修复

Huan Li¹, Chang Chen², Xinzhu Chen¹

¹College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.

British journal of pharmacology

|March 11, 2025

概括

研究人员确定了Sanzhiside甲基 (SM),8-O-乙shanzhiside甲基 (ASM) 和Phlorigidoside C (PhC) 作为Lamiophlomis rotata提取物中的关键化合物,可以加速伤口愈合. 发现这些标记物在颗粒组织中增加,改善生物可用性.

科学领域:

药理学药理学是指药理学的学科.
自然产品化学化学
伤口治愈研究研究伤口治愈研究

背景情况:

之前已经证明,Lamiophlomis rotata (IGLR) 的虹膜糖化物提取物通过诱导M2巨细胞极化来加速伤口愈合.
负责这种效果的特定活性化合物 (质量标志物) 仍未确定.

研究的目的:

在IGLR中确定负责加速伤口愈合的质量标记.
阐明这些已识别的化合物在伤口愈合过程中的作用.

主要方法:

带有背部切割伤口的小鼠和正常的小鼠在7天内用IGLR进行了测试.
使用矩阵辅助激光脱/电离质谱成像 (MALDI-MSI) 分析了组织.
使用超高性能液态色谱/质谱 (UPLC-MS) 与多变量分析相结合,验证了结果.

主要成果:

在IGLR中,香化甲基 (SM),8-O-乙香化甲基 (ASM) 和Phlorigidoside C (PhC) 被确定为质量标志物.
这些标记物与内源代谢物如乳酸盐,酸盐和伊塔康酸盐重叠.
在伤口组的肝脏中观察到SM,ASM和PhC的积累增加,这表明生物可用性有所改善.

结论:

在新的颗粒组织中选择性增加了SM,ASM和PhC.
这些化合物被确定为最可能加速伤口愈合的质量标志物.
这些发现为IGLR的质量控制和治疗开发提供了基础,用于伤口愈合.

关键词:

拉米奥弗洛米斯旋转型化物糖化物 (iridoid glycosides) 是一种化物糖化物.质谱仪成像成像质谱仪成像成像质量标志物质量标志物质量标志物质量标志物质量标志物伤口修复伤口修复

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