高脂肪饮食对唾液和肠道微生物群的不同影响
Jingxuan Bai1,2, Yixue Tian1,2, Yujia Lu1,2
1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
Frontiers in cellular and infection microbiology
|March 11, 2025
概括
高脂肪饮食会改变小鼠的口腔和肠道微生物群,一些共同的微生物变化可能通过代谢途径和炎症导致肥胖.
科学领域:
- 微生物学 微生物学
- 肥胖问题研究研究
- 转基因组学是指转基因组学.
背景情况:
- 微生物在肥胖病原发生过程中发挥着作用,重点是肠道微生物群.
- 口腔微生物群和肥胖之间的关系仍未得到充分研究.
研究的目的:
- 研究高脂肪饮食对小鼠唾液和肠道微生物群的影响.
- 探索口腔微生物机制导致肥胖的假设.
主要方法:
- 建立了一个高脂肪饮食诱导的肥胖小鼠模型.
- 使用16S rRNA测序分析了唾液和肠道微生物群.
- 通过气色谱-质谱测量量量化短链和中链脂肪酸.
主要成果:
- 高脂肪饮食改变了唾液微生物群的组成,增加了*Streptococcus*和*Escherichia*.
- 肠道微生物群多样性受到更大的影响,增加了*Kineothrix*和*Cryptobacteroides*.
- 在口腔和肠道微生物群中,有9个属表现出一致的变化,其中一些与生理指标和代谢途径相关.
结论:
- 高脂肪饮食会导致唾液和肠道微生物群的明显但重叠的变化.
- 口腔-肠轴的微生物变化可能通过代谢和炎症途径影响肥胖.
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