与受创伤影响的对照人群相比,患有PTSD的个体的肠道微生物群差异:系统性审查
Chantelle Winder1,2, Ami Lodhia3, Melissa Basso1
1Social Brain and Development Lab, School of Psychology, University of Surrey, Guildford, United Kingdom.
Frontiers in neuroscience
|March 11, 2025
概括
在患有创伤后应激障碍 (PTSD) 的个体中存在肠道微生物组差异. 特定的细菌种群可能会增加PTSD风险或提供弹性,这表明潜在的肠-大脑轴干预.
科学领域:
- 神经科学和微生物学
- 肠-大脑轴研究研究
- 心理健康和微生物群的相互作用
背景情况:
- 创伤后应激障碍 (PTSD) 是创伤暴露后的一个虚弱的心理健康状况.
- 创伤后应激障碍背后的机制尚未完全理解,但肠道异常表明肠道微生物组和肠-大脑轴的作用.
- 以前的研究将肠道微生物组与各种精神健康障碍联系起来,但其在PTSD中的具体作用仍然不清楚.
研究的目的:
- 系统地审查和综合有关PTSD和创伤暴露对照 (TEC) 个体之间的肠道微生物组差异的现有文献.
- 探索与肠道微生物组组成相关的PTSD发展的潜在风险和弹性因素.
- 确定针对肠道微生物组的新型PTSD治疗的含义.
主要方法:
- 对比患有PTSD和TEC的个体肠道微生物组合的研究进行系统审查.
- 纳入标准侧重于检查微生物种群差异及其与PTSD相关性的研究.
- 文献搜索和综合符合条件的研究结果.
主要成果:
- 三项研究符合纳入标准,所有研究都报告了PTSD和TEC组之间的肠道微生物种群的差异.
- 一项研究发现,在患有PTSD的人群中,肠道微生物多样性显著降低.
- 特定的属 (例如,Mitsuokella,Odoribacter) 和属 (例如,Actinobacteria,Verrucomicrobia) 与PTSD症状严重程度相关.
结论:
- 肠道微生物组的组成在患有PTSD和没有PTSD的个体之间有所不同,这表明它参与了这种疾病.
- 某些肠道微生物特征可能代表风险因素或防止PTSD发展的保护因素.
- 研究结果支持针对微生物组的干预措施的潜力,例如精神病菌药物,用于PTSD治疗,尽管需要进一步研究更大的样本大小和受控变量.
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