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通过高湿度和高温度的低度臭氧对空气传播病毒的协同无效化
Hidekazu Nishimura1, Soichiro Sakata2, Isolde Dapat1
1Clinical Research Division, Virus Research Center, Sendai Medical Center, National Hospital Organization, Sendai, Japan.
Microbiology and immunology
|March 11, 2025
概括
低臭氧度与高湿度和温度相结合,有效地使空气传播的流感和冠状病毒失活. 这一发现表明对现实世界的病毒传播动态有重大影响.
科学领域:
- 环境科学 环境科学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 空气传播病毒的生存能力受到环境因素的影响,如湿度,温度和臭氧.
- 臭氧与湿度和温度对空气传播病毒的协同作用仍然不太清楚.
研究的目的:
- 调查空气流感病毒和冠状病毒在低臭氧,不同相对湿度 (RH) 和温度条件下的无活化.
- 了解这些因素对病毒基因拷贝数量和感染性的影响.
主要方法:
- 病毒液被原子化成一个受控的腔室,其中包含特定的臭氧,RH和温度组合.
- 气溶液中的病毒颗粒被暴露在冷却空气中,并取样以进行定位以确定活性病毒水平.
- 使用定量实时聚合酶链反应 (qPCR) 来评估病毒基因拷贝数量.
主要成果:
- 与0ppb臭氧相比,在50%-85%的RH下,在15-55ppb臭氧下观察到活跃病毒水平的显著降低.
- 最小的病毒无活化发生在<40%的RH,即使有100ppb的臭氧.
- 病毒基因拷贝数在各种条件中保持一致,表明非激活而不是降解.
- 无活化随着温度的增加而增加,除了在15°C外.
结论:
- 低环境臭氧度,特别是与高湿度和高温相结合时,有效地使空气流感和冠状病毒无效.
- 这些环境条件可能在自然环境中调节空气传播病毒传播方面发挥关键作用.
- 需要进一步的研究,以探索在不同的环境条件下臭氧介导的病毒失活的精确机制.
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