时间型,睡眠时间,睡眠规律和癌症风险:系统性审查
Sidney M Donzella1, Benjamin N Bryer1, Trang VoPham1,2
1Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA.
Sleep
|March 11, 2025
概括
这一系统性审查没有发现一致的证据,将睡眠时间,规律性或时间型与癌症风险联系起来. 需要更多的研究来规范睡眠测量,并确认在不同人群中发现的结果.
科学领域:
- 流行病学 流行病学
- 睡眠科学 睡眠科学
- 在瘤学瘤学.
背景情况:
- 睡眠是影响癌症风险的可修改的生活方式因素.
- 研究越来越多地关注睡眠时间和规律性,而不仅仅是持续时间.
- 了解这些因素对于癌症预防策略至关重要.
研究的目的:
- 系统地审查和综合现有关于时间型,睡眠时间和睡眠规律与癌症风险之间的关系的文献.
- 识别当前研究结果中的模式和不一致性.
- 突出未来睡眠和癌症流行病学的研究领域.
主要方法:
- 2024年10月,在四个主要数据库 (PubMed,CINAHL,PsychInfo,Embase) 中进行了系统的文献搜索.
- 包括的研究重点是睡眠时间,规律性,时间型,社会时差和周末追赶睡眠作为暴露和癌症发病率作为结果.
- 包括22项研究,其中大多数使用自我报告的睡眠问卷和评估特定地点的癌症发病率.
主要成果:
- 没有找到一致的证据将晚期时刻型,晚期睡眠中点,增加社交时差或周末追赶睡眠与癌症风险增加联系起来.
- 大多数研究 (95%) 依赖于自我报告的睡眠数据.
- 在研究中的睡眠时间和规律性评估方法中观察到显著的异质性.
结论:
- 目前的证据将睡眠时间,睡眠规律和时间型与癌症风险联系在一起是不确定的.
- 在未来的研究中,需要标准化措施来量化睡眠时间和规律性.
- 在不同种群中进行复制研究对于加强证据基础至关重要.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
01:13Insufficient Sleep and Sleep Deprivation
138
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
138
01:11Understanding Sleep
224
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
224
01:19Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
01:19Management of Insomnia
237
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
237
01:21Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334