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具有增强稳定性的多功能脂质体,用于成像导向的癌症化学动力学和光热疗法

Jingyu Zhang¹, Ren Fang², Ningning Song²

¹School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300350, P. R. China.

ACS biomaterials science & engineering

|March 11, 2025

概括

一个新的纳米平台,MA@E,有效地使用活性氧物种 (ROS) 和光热疗法去除瘤. 这种多功能系统在临床前模型中显示出增强癌症治疗的前景,毒性最小.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

有针对性的癌症治疗需要创新的策略,结合多种治疗方式.
开发稳定的纳米载体以有效地输送治疗剂对于有效的瘤去除至关重要.
反应性氧物种 (ROS) 生产和光热转化是癌症治疗中的有希望的方法.

研究的目的:

为增强瘤治疗开发和评估一个多功能纳米平台 (MA@E).
研究ROS生成和光热转换在瘤去除中的协同效应.
在小鼠瘤模型中评估MA@E的疗效和安全性.

主要方法:

MA@E纳米平台使用封装黄金纳米棒 (AuNRs) 的增强稳定性脂质体和Mn-MIL-100金属有机框架开发.
MA@E被输送到瘤细胞的细胞质中,以进行向性化.
通过GSH耗尽和由释放的Mn2+触发的芬顿式反应产生ROS.
通过近红外 (NIR-II) 辐射诱导的光热转化,以增强Mn2+释放和ROS生产.

主要成果:

MA@E有效地减少了瘤细胞中的减少型谷氨 (GSH),增加了基的产生.
NIR-II辐射增强了Mn2+释放和ROS生成,导致基 (•OH) 生产增加.
在小鼠瘤模型中,MA@E在2天内实现了完全的瘤去除,没有可观察到的毒性影响.

结论:

MA@E纳米平台通过联合光热和化学动力学疗法展示了强大的协同作用的抗癌效应.
MA@E促进了高效的ROS生成和向性瘤破坏.
这种方法为利用不稳定的纳米材料在有效的瘤治疗中提供了一个有希望的策略.

关键词:

化学动态疗法化学动态疗法金属有机的框架.多功能的纳米粒子.光热疗法是一种光热疗法.稳定的交付稳定的交付

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