来自Piper longum L.具有抗炎和抗糖尿病作用的二氧化二氧化胺类类酶体
Guanghui Gou1,2, Liu Liu1, Wenli Bao1,2
1State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, China.
Journal of agricultural and food chemistry
|March 11, 2025
概括
这项研究从Piper longum水果中分离出新的二元胺基化物,揭示了治疗开发的显著抗炎和潜在抗糖尿病活性.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- Piper longum L. (Piperaceae) 的果实是一种具有已知的药用特性的香料.
- 滴氨酸胺基类化合物是一种具有多种生物活性的化合物.
- 基于分子网络的脱复制是一种有效的自然产品隔离策略.
研究的目的:
- 从Piper longum水果中分离和表征新的二次胺类类酶体.
- 评估隔离化合物的体外抗炎,α-葡萄糖酶抑制和PTP1B抑制活性.
主要方法:
- 基于分子网络的脱复制策略用于化合物隔离.
- 综合的光谱数据,电子圆二元化 (ECD) 计算和X射线衍射分析用于结构阐明.
- 基拉分辨率和体外生物活性查 (抗炎,α-葡萄糖酶,PTP1B抑制).
主要成果:
- 隔离了12个二极体胺基类化物酶体 (1-12),包括8个循环butan型二极体 (1-8) 和4个循环赫类二极体 (9-12).
- 确定了五种新型的循环butan型二元体 (piperlongramides E-I,1-5) 和一种新型的循环赫森型二元体 (piperlongramide J,9).
- 化合物 (+) - 10, (-) - 10 和 (+) - 3 显示出抗炎作用; (+) - 3 抑制了α-葡萄糖酶; (+) - 9, (+) - 7 和 (-) - 9 抑制了PTP1B,表明潜在的抗糖尿病作用.
结论:
- 这项研究成功地从Piper longum中分离和表征了新的二次胺类化物.
- 一些孤立的化合物表现出有前途的抗炎和抗糖尿病活性.
- 这些发现支持Piper longum衍生的化合物在功能性食品和药品中的潜在用途.
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