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科罗拉多州石油和天然气开发和儿童白血病风险的暴露:基于人口的病例控制研究.

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  • 1Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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居住在石油和天然气场所附近的儿童面临患急性淋巴细胞白血病 (ALL) 的风险更高. 靠近这些地点,特别是在5公里范围内,显著增加了儿童白血病风险,这表明目前的安全挫折可能不足.

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科学领域:

  • 环境健康 环境健康
  • 流行病学 流行病学
  • 儿科瘤学 儿科瘤学

背景情况:

  • 在上游石油和天然气 (O&G) 运营地区的儿童可能会接触到白血病原体.
  • 这种暴露与急性淋巴细胞白血病 (ALL) 的风险增加有关.

研究的目的:

  • 调查科罗拉多州上游O&G活动与儿童ALL风险之间的关联.
  • 评估O&G井站点当前住宅挫折的有效性.

主要方法:

  • 一项涉及451名被诊断患有ALL的儿童和2,706名在科罗拉多州 (1992-2019) 的匹配对照的病例对照研究.
  • 估计上游O&G活动强度使用强度调整的逆距离加权 (IA-IDW) 模型从概念到10年的延迟.
  • 使用后勤回归模型来评估ALL和IA-IDW之间的关系,并对混因素进行调整.

主要成果:

  • 居住在O&G井地点5公里以内的儿童在低,中,高IA-IDW组 (ORs从1.62到2.00) 中显示ALL风险增加.
  • 在13公里范围内,所有IA-IDW组都观察到ALL风险增加 (ORs从1.40到2.64).
  • 最高的风险与O&G井地点的邻近和更高的暴露强度有关.

结论:

  • 科罗拉多州儿童居住在O&G井地点13公里以内,面临ALL风险较高,最大风险在5公里以内.
  • 目前O&G井站点和住宅之间的监管挫折可能不足以保护儿童的健康.
  • 研究结果支持制定政策,以减轻儿童白血素暴露.