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Updated: May 23, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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使用药理动力学和药理动力学分析来优化Fanastomig (EMB-02) 在患有高级固体瘤的患者的剂量方案

Chengjun Jiang1, Fang Ren1, Mingfei Zhang1

  • 1Hanghai EpimAb Biotherapeutics Co., Ltd, Shanghai EpimAb Biotherapeutics, Shanghai, China.

CPT: pharmacometrics & systems pharmacology
|March 11, 2025
PubMed
概括

范阿斯托米格 (Fanastomig) 是一种用于高级固体瘤的新型双特异性抗体,在I期试验中表现出良好的耐受性和安全性. 使用人口药理动力学和暴露-反应建模,确定了推的II期剂量.

关键词:
我是一个狂热的粉丝.剂量优化剂量优化暴露和反应的暴露和反应.淋巴细胞激活基因-3 (LAG-3).人口的药理动力学模型.编程细胞死亡蛋白1 (PD-1) 编程细胞死亡蛋白1接收器占用率 接收器占用率

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