Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

367
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
367
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

612
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
612
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Gamma oscillations provide a stable geometric scaffold for color representation in primate inferior temporal cortex.

Communications biology·2026
Same author

Discovering Novel intracranial EEG Biomarkers of Seizure Generating Tissue through Time-Frequency Analysis.

medRxiv : the preprint server for health sciences·2026
Same author

Positron Emission Tomography (PET) in Phenylketonuria: A Systematic Review of Brain Metabolism Beyond Phenylalanine.

American journal of medical genetics. Part A·2026
Same author

Endoscopic Visualization of a Jejuno-Colonic Fistula in a Case of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma.

DEN open·2026
Same author

Efficacy and safety of nintedanib for older adults with idiopathic pulmonary fibrosis or progressive fibrosing interstitial lung disease: A multicenter retrospective study in Japan.

Respiratory investigation·2026
Same author

Baseline neutrophil-to-lymphocyte ratio predicts survival time after the initiation of nintedanib in patients with interstitial lung disease.

BMC pulmonary medicine·2026

相关实验视频

Updated: May 23, 2025

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.2K

视觉遗传诱导的持续的下丘脑过度兴奋会通过丘脑扩散损害记忆.

Masaki Sonoda1,2, Hisao Aimi1,2, Keisuke Kawasaki1

  • 1Department of Physiology, Niigata University School of Medicine, Niigata, Japan.

Epilepsia
|March 11, 2025
PubMed
概括

过度的神经突发从下丘脑哈马托马 (HH) 到中背丘脑损害工作记忆. 这项研究揭示了HH相关脑病变中认知问题背后的一个关键机制.

关键词:
基于剥离的儿科手术.计算式的内EEG分析性脑病 - - 性脑病网络的发症网络由光遗传学诱导的异常神经刺激.

更多相关视频

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
09:43

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

2.4K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.6K

相关实验视频

Last Updated: May 23, 2025

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.2K
Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
09:43

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

2.4K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.6K

科学领域:

  • 神经科学是一个神经科学.
  • 发病学 (Epileptology) 是一个专业的学科.
  • 认知科学 认知科学

背景情况:

  • 脑下垂体瘤 (HH) 与玻璃性和认知功能障碍有关.
  • 假设从HH中产生的间接性发泄物 (IED) 会导致认知缺陷.
  • 了解涉及的神经通路对于开发向疗法至关重要.

研究的目的:

  • 提供因果证据,证明HH的IEDs会损害工作记忆.
  • 为了研究神经刺激从HH传播到中背丘脑的神经刺激传播的作用.
  • 阐明HH相关性脑病变中认知障碍的病理生理机制.

主要方法:

  • 道罗多普辛-2光刺激在老鼠中被用于模仿横向下丘脑 - 中背丘脑通路中的IED.
  • 记录了局部场电位 (LFP),并使用和不使用光刺激来执行工作记忆任务.
  • 支持矢量机器分析确定了成功执行任务的神经相关性,混合模型分析评估了光刺激效应.

主要成果:

  • 成功的工作记忆试验与更短的维护时间相关,并在编码过程中增加了中背丘脑和前皮质中的10-14赫兹LFP振幅.
  • 在编码过程中中背部中丘脑的光刺激使试验的成功率降低了0.19.
  • 在编码过程中过度的中脊柱体LFP增强使得试验失败的几率增加了1.04.

结论:

  • 在记忆编码过程中,从侧向下丘脑到中背丘脑的过度神经刺激会暂时损害工作记忆.
  • 这种途径的改变破坏了生理神经活动,导致认知缺陷.
  • 这些发现澄清了HH相关性脑病变中工作记忆障碍的机制.