在接受放射治疗的前列腺癌患者中,肠道疾病的发生率和直肠间隙的使用
Michael R Folkert1, Ryoko Sato2, James B Yu3
1Department of Radiation Oncology, University of Washington School of Medicine, Seattle.
JAMA network open
|March 11, 2025
概括
在前列腺癌放射治疗期间使用基于聚乙烯糖醇的水凝间隔器 (PHS) 可以显著减少肠道疾病和相关程序. 接受PHS的患者经历的结果与一般人群相似,与没有PHS的患者不同.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 胃肠病学 胃肠病学
背景情况:
- 前列腺癌放射治疗 (RT) 可以导致肠道疾病.
- 在RT期间,使用基于聚乙烯糖醇的水凝间隔器 (PHS) 来将直肠与前列腺分离.
研究的目的:
- 为了比较肠道疾病和相关手术的发病率,前列腺癌患者接受了带有和没有PHS的RT.
主要方法:
- 使用四个大型美国医疗保健数据库 (2015-2021) 进行的回顾性队列研究.
- 包括成年前列腺癌患者接受RT.
- 将接受PHS和未接受PHS的患者之间的结局进行比较,并与一般人群进行比较.
主要成果:
- 在RT后4年,接受PHS的患者与没有PHS的患者相比,患肠道疾病的风险降低了25%,相关手术的风险降低了46%.
- 在PHS组中,肠道疾病和手术的发生率与年龄相匹配的普通人群相似.
- 与一般人群相比,没有PHS的患者表现出明显更高的肠道疾病和手术风险.
结论:
- PHS显著降低了前列腺癌后肠道疾病和相关程序的发生率RT.
- 使用PHS似乎可以减轻前列腺癌放射治疗的长期胃肠道副作用.
- 研究结果支持使用PHS来改善前列腺癌后患者的治疗结果和生活质量.
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