慢性病中的饮食摄入量和肠道微生物群
Julie Ann Kemp1, Marcia Ribeiro2, Natália A Borges3
1Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil.
概括
肠道失调,肠道微生物的不平衡,影响慢性病 (CKD) 通过肠轴的进展. 针对微生物组的饮食改变为CKD患者提供了治疗潜力.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群的不平衡,即肠道失生症,越来越多地被认为是慢性病 (CKD) 进展的一个因素.
- 肠-轴描述了肠和之间的双向通信,其中微生物变化影响全身炎症和尿素毒素积累,恶化损伤.
研究的目的:
- 审查肠道微生物组和肠轴在CKD中的作用.
- 探索饮食干预措施和新兴的微生物向疗法,以管理慢性病.
- 确定未来的研究方向,以了解和治疗CKD.
主要方法:
- 文献综述侧重于慢性脏病中的肠轴.
- 分析饮食对肠道微生物群组成和CKD的影响.
- 检查针对肠道失调和失代物质的新型治疗策略.
主要成果:
- 饮食显著塑造肠道微生物群,影响CKD进展和相关疾病,如心血管疾病.
- 来自微生物群的失代代谢物代表了减少CKD尿素和心血管毒性的治疗目标.
- 目前对肠-轴的理解有限,需要对各种微生物群落进行更广泛的研究.
结论:
- 饮食干预对于通过调节肠道微生物群来管理CKD至关重要.
- 准肠道微生物群及其代谢物为CKD提供了有前途的治疗途径.
- 未来的研究应该涵盖更广泛的微生物 (真菌,古生物,病毒),以全面了解肠轴和个性化CKD治疗.
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