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在CKD的背景下,家族史
Francesca Zanoni1,2, Maddalena Marasa2, Lucrezia Carlassara2
1Department of Nephrology, Dialysis, and Kidney Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Journal of the American Society of Nephrology : JASN
|March 11, 2025
概括
糖尿病等疾病的家族病史增加了慢性病 (CKD) 患者的并发症风险. 糖尿病的家族史,而不是CKD,独立地预测CKD进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 遗传学 遗传学是一种遗传学.
- 流行病学 流行病学
背景情况:
- 家庭病史可能表明疾病的共同遗传/环境风险.
- 家庭病史对慢性病 (CKD) 患者结局的影响尚未完全理解.
- 调查家族病史在CKD并发症和进展中的作用至关重要.
研究的目的:
- 检查CKD患者的CKD家族病史,糖尿病和其他伴随疾病的疾病之间的关联.
- 为了确定家族病史是否会影响患有慢性病的个体的病进展.
主要方法:
- 对两个潜在的CKD队列 (治愈淋巴细胞病症网络和慢性功能不全队列) 的观察性研究.
- 包括2573名成人和儿童和3939名成年参与者.
- 用多变量模型分析了自报告的一级家族病史数据,分析了同伴病症和CKD进展的关联.
主要成果:
- 糖尿病,癌症和心血管疾病的家族病史与CKD患者中这些疾病的风险更高相关.
- 糖尿病的家族病史独立预测了CKD的进展,无论糖尿病状态或糖尿病的多基因风险评分 (PRS).
- 虽然CKD PRS预测了CKD的进展,但CKD家族史并不能独立预测现有的CKD患者的进展.
结论:
- 收集家族病史数据可以提高CKD患者的临床风险分层.
- 糖尿病的家族病史是CKD进展的重要,独立的预测因素.
- 家庭病史为CKD风险和进展提供了宝贵的见解,不仅仅是遗传倾向.
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