相关实验视频
Updated: May 23, 2025

01:37
A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
293
孕期阿片类药物暴露:从吗啡到MOUD-阿片类药物如何影响后代发育和母亲的护理
Jecenia Duran1, Sonia Khalid2, Lauren Richardson1
1Department of Psychology, Wayne State University, Detroit, MI, USA.
Current topics in behavioral neurosciences
|March 11, 2025
概括
阿片类药物使用障碍影响着许多生育年龄的女性. 布普伦诺芬 (BUP) 在怀孕期间治疗阿片类药物使用障碍方面表现有前途,但长期婴儿和母婴的结果需要进一步研究.
科学领域:
- 生殖健康 生殖健康
- 新生儿戒断综合征 新生儿戒断综合征
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物使用障碍 (OUD) 是一个重要的全球健康问题,加剧了美国的高处方率.
- 生殖年龄的妇女受到不成比例的影响,导致产前阿片类药物暴露增加,随后婴儿暴露.
- 治疗阿片类药物使用障碍 (MOUD) 的药物,包括甲和布普伦诺芬 (BUP),是标准治疗方法.
研究的目的:
- 审查关于妊娠期阿片类药物暴露对后代结果影响的当前文献.
- 为了比较在怀孕期间暴露于吗啡 (非法物质) 和布普伦诺啡 (MOUD) 的影响.
- 为了确定关于BUP对母婴二代的长期影响的知识差距.
主要方法:
- 对检查妊娠期阿片类药物暴露的研究的文献综述.
- 专注于与吗啡和布普伦诺芬暴露相关的结果.
- 分析母亲和婴儿的结果,包括母婴亲密关系和护理行为.
主要成果:
- 布普伦诺芬 (BUP) 越来越多地比甲在怀孕期间用于OUD治疗,因为它在遵守,戒断和婴儿后果方面具有感知上的好处.
- BUP暴露对后代和母婴双的长期影响仍然不完全理解.
- 现有文献强调,需要对孕后阿片类药物暴露的孕产妇护理行为和母婴联系进行更多研究.
结论:
- 虽然BUP在怀孕期间对OUD治疗有希望,但对其长期影响缺乏全面的了解.
- 进一步的研究至关重要,以阐明妊娠期阿片类药物使用 (包括BUP) 对母亲福祉和母婴关系的全部影响.
- 解决OUD在怀孕中的复杂性需要继续调查治疗疗效和长期二次结果.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
203
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
203
Opioid Analgesics: Morphine and Other Natural Cogeners
159
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
159
Analgesia and Pain Management
420
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
420
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Opioid Receptors: Overview
420
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
420
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
213
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
213

