半体对生活质量的影响,使用CIPHER前性队列研究数据
Joel Glynn1, William Hollingworth2, Jessica Harris3
1Health Economics and Health Policy (HEHP), Bristol Medical School, University of Bristol, Bristol, UK. joel.glynn@bristol.ac.uk.
概括
副口腔 (PSH) 显著降低了口腔患者的与健康相关的生活质量 (HRQoL),导致质量调整后生命日的大量损失. 开发预防性外科手术技术对于减轻这些负面影响至关重要.
科学领域:
- 医学和健康科学医学和健康科学
- 外科手术的结果
- 患者报告的结果
背景情况:
- 副胃 (PSH) 是一个常见的并发症后口腔外科手术.
- 对于PSH对与健康相关的生活质量 (HRQoL) 的影响尚不清楚.
- 了解这种影响对于改善患者护理和外科手术策略至关重要.
研究的目的:
- 调查自报的PSH和HRQoL在口腔患者之间的关联.
- 量化PSH对HRQoL各个维度的影响.
- 估计与PSH相关的质量调整生命日 (QALDs) 的损失.
主要方法:
- 利用来自大型CIPHER前性队列研究的数据.
- 在12个月内使用EuroQol-5D-5L (EQ-5D-5L) 仪器收集了2,341名个人HRQoL数据.
- 使用重复测量和顺序回归分析来评估PSH和HRQoL结果之间的关联.
主要成果:
- 患有PSH的患者在手术后12个月报告了显著较低的EQ-5D-5L得分 (-0.099).
- PSH与每人/年估计损失22.3个QALD有关.
- 患有PSH的个体在所有五个EQ-5D-5L维度中都经历了更多的问题,在四个维度中HRQoL恶化的几率翻了一番,最显著的是疼痛/不适 (OR 2.80).
结论:
- 发展PSH显著降低HRQoL,影响疼痛,日常活动,自我护理,移动性和情感福祉.
- 强调开发和评估用于预防PSH的外科手术技术的重要性.
- 提供HRQoL估计,可以为针对PSH预防的干预措施的成本效益分析提供信息.
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