环境空气污染,绿地和明显的生物衰老之间的关联:一个横截面研究
Yijing Zhao1,2, Xuena Yang1, Dan He1
1Key Laboratory of Trace Elements and Endemic Diseases, School of Public Health, National Health and Family Planning Commissionhealth Science Centerjiaotong University, Xi'an, 710061, China.
GeroScience
|March 11, 2025
概括
空气污染加快了生物衰老,而绿色空间减缓了它. 这些环境因素影响健康,某些群体对污染和绿色空间暴露的敏感性增加.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 老龄化是非传染性疾病的主要危险因素.
- 空气污染和绿地等环境因素对人类健康有很大的影响.
- 环境暴露和衰老过程之间的相互作用仍未得到充分研究.
研究的目的:
- 调查空气污染,绿地和生物衰老之间的联系.
- 在一个大规模的英国队列中,使用PhenoAge算法量化生物衰老加速.
- 探索不同的人口和生活方式因素之间的差异性影响和相互作用.
主要方法:
- 利用了来自156,690个人的英国生物库数据.
- 使用基于临床特征的PhenoAge算法估计的生物年龄.
- 使用线性回归来分析环境暴露 (空气污染,绿地) 和表型年龄加速 (PhenoAgeAccel).
- 进行了子组分析,并探索了与生活方式因素的相互作用效应.
主要成果:
- 在空气污染 (PM2.5,PM10) 和PhenoAgeAccel之间发现了正相关性.
- 在绿色空间暴露和PhenoAgeAccel之间观察到负相关性.
- 非吸烟者,前吸烟者,饮酒者,肥胖/超重个体和女性对环境暴露的敏感性增加.
- 在PhenoAgeAccel上,酒精摄入量与环境因素之间的已识别的相互作用效应.
结论:
- 空气污染与加速的生物衰老有关.
- 增加绿色空间与减缓生物衰老有关.
- 环境暴露及其对老龄化的影响在不同的人口子组之间有所不同,这突显了有针对性的公共卫生干预措施的需要.
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