相关实验视频
Updated: May 23, 2025

05:16
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
6.5K
低血糖指数配方对胃切除术后胃癌患者低血糖的有效性:随机交叉研究
Takeshi Kubota1, Takuma Ohashi1, Keiji Nishibeppu1
1Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
BJS open
|March 11, 2025
概括
一种专门的配方改善了胃切除术后患者的夜间低血糖症. 然而,它没有显著改变白天葡萄糖水平或倾销综合征症状,表明需要进一步的营养研究.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 胃切除术的患者有食后和夜间低血糖症的风险,以及晚期倾倒综合征.
- 目前对胃切除术后低血糖症的管理策略主要依赖于患者的自我管理.
- 正在探索营养干预措施,以减轻这些常见的术后并发症.
研究的目的:
- 调查低碳水化合物/高单不和脂肪酸配方在改善胃切除术后低血糖症方面的有效性.
- 评估这种营养配方对血糖变异性和倾销症状的影响.
- 探索胃切除术后胃癌患者的营养优化策略.
主要方法:
- 进行了一项单中心,前性,开放标签,随机交叉研究.
- 参与者在饭后和睡前消耗了100毫升低碳水化合物/高单不和脂肪酸配方 (400千卡/天).
- 使用持续的血糖监测和症状评估来评估配方对时间低于范围和变化系数的影响.
主要成果:
- 该配方显著改善了远端胃切除术患者的夜间低血糖症 (P < 0.001),并且显示了全胃切除术患者的趋势 (P = 0.078).
- 日间时间低于范围和变化系数,即迟倾销综合征的指标,没有显著改善.
- 距离胃切除术患者的夜间平均时间下降,从3.5%降至1.4%.
结论:
- 低碳水化合物/高单不和脂肪酸配方有效地改善了胃切除术后的夜间低血糖症.
- 该配方没有显著影响白天血糖变化或低血糖,这表明在解决迟倾销综合征方面存在局限性.
- 对营养优化的进一步研究是必要的,以全面管理胃切除术后的并发症.
相关概念视频
Hypoglycemia and Glucagon
148
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
148
Oral Hypoglycemic Agents: Biguanides and Glitazones
149
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
149
Oral Hypoglycemic Agents: Glinides
127
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
127
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
141
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
141
Glucagon-like Receptor Agonists
289
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
289
Dipeptidyl Peptidase 4 Inhibitors
155
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
155

