描述印尼阿切省Plasmodium knowlesi的遗传多样性和种群结构
Pinkan P Kariodimedjo1,2, Nadia Fadila1, Sydney R Fine3
1Malaria Pathogenesis Unit, Eijkman Institute for Molecular Biology, Jakarta Pusat, Daerah Khusus Jakarta, Indonesia.
PloS one
|March 11, 2025
概括
人类感染灵长类疟疾寄生虫Plasmodium knowlesi (P. knowlesi) 威胁着印度尼西亚的疟疾消除. 这项研究发现,阿切岛的P. knowlesi菌株在遗传上是不同的,多样性最小的,这表明局部传播.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 分子流行病学分子流行病学
- 传染病的动态传染病的动态.
背景情况:
- 东南亚的疟疾消除工作受到人类感染Plasmodium knowlesi的增加的挑战,这是一个猿类疟疾寄生虫.
- 了解P. knowlesi的遗传多样性和种群结构对于印尼有效的疟疾控制和消除战略至关重要.
研究的目的:
- 调查印尼阿切省Plasmodium knowlesi的遗传多样性和种群结构,这是一个接近消除疟疾的地区.
- 评估P. knowlesi在一个正在进行疟疾消除工作的地区的传播动态.
主要方法:
- 从2014年6月到2018年9月进行了分子监测,收集了疟疾阳性患者的样本.
- 用PCR进行了物种确认和鉴定,随后使用10个微观卫星标记器对41个P. knowlesi样本进行了基因定型.
- 用各种统计方法分析了遗传多样性,人口结构和感染复杂性,包括主要坐标和邻近连接分析.
主要成果:
- 确认了46例P. knowlesi感染,基因型检测显示基因多样性低 (预期异构性[HE]=0.63) 和复杂性低 (92.7%的单克隆感染).
- 分析表明,寄生虫群体内的遗传交换是最小的 (关联指数[IAS] = 0.008).
- 来自阿切的Plasmodium knowlesi菌株与马来西亚报告的菌株在遗传上有所不同,这表明局部传播模式.
结论:
- 印尼阿切岛的Plasmodium knowlesi菌株具有较低的遗传多样性,与马来西亚菌株不同,表明传染高度局部化.
- 这些发现凸显了持续基因监测的重要性,以追踪P. knowlesi,并为印尼的疟疾控制和消除战略提供信息.
- 独特的遗传特征表明,印尼和马来西亚P. knowlesi种群之间的联系有限.
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