相关实验视频

Updated: May 3, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

11.8K

在中性pH下启动transthyretin聚合,通过液体动

Irina Ritsch1, H Jane Dyson1, Peter E Wright1

  • 1Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, Scripps Research, La Jolla, CA 92037.

Proceedings of the National Academy of Sciences of the United States of America
|March 11, 2025
PubMed
概括

液体剪切力,不仅仅是pH值的变化,可以触发TTR聚合. 这一过程涉及到四聚离子解离和粉胺基中间体的形成,为transthyretin amyloidosis提供了新的见解.

关键词:
聚合机制的聚合机制.氨基粉症是什么?流体剪切 流体剪切人类的跨甲状腺素.

更多相关视频

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.3K
Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

7.9K

相关概念视频

Energy to Drive Translocation01:37

Energy to Drive Translocation

Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
2.0K