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种族对端粒长度和代谢标记之间的关系的影响 - - 来自科威特的一项多民族研究

Thangavel Alphonse Thanaraj¹, Mohamed Abu-Farha^2,3, Ahmed N Albatineh⁴

¹Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.

The Journal of clinical endocrinology and metabolism

|March 11, 2025

概括

种族显著影响端粒长度和代谢健康. 纳入种族背景对于使用端粒长度作为糖尿病风险评估的生物标志物至关重要.

科学领域:

遗传学和基因组学遗传学和基因组学
代谢健康和内分泌学
生物标志物发现发现

背景情况:

端粒长度是细胞衰老的标志物,也是代谢疾病的潜在风险因素.
了解种族对端粒长度的影响对于其临床应用至关重要.

研究的目的:

在多民族队列中检查端粒长度,人口因素和代谢健康之间的关联.
调查种族对端粒长度的影响,作为糖尿病风险的潜在生物标志物.

主要方法:

在科威特对来自阿拉伯,南亚和东南亚族群的2,083人进行了横截面研究.
端粒长度用从外周血液DNA中测量的qPCR.
统计分析包括斯皮尔曼相关性和量子力回归,调整为共变量.

主要成果:

南亚和东南亚人比阿拉伯人有更长的端粒.
端粒长度因性别,年龄,种族,糖尿病状况,BMI和HOMA-IR而有显著差异.
端粒长度与男性性别,糖尿病,年龄,HOMA-IR,BMI和HbA1c有负相关性,南亚人之间的相关性更强.

结论:

种族显著影响端粒长度和代谢健康之间的关系.
在使用端粒生物学来评估代谢障碍时,必须考虑种族背景.
端粒长度显示了将其纳入临床糖尿病风险评估中的潜力.

关键词:

阿拉伯人阿拉伯人阿拉伯人端粒长度端粒长度端粒长度糖尿病糖尿病患者糖尿病患者胰岛素耐药性是一种胰岛素耐药性.代谢标志物的代谢标志物多民族多民族的身份.

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