帕利皮里诱导的神经乱性恶性综合征:一个病例报告
1Clinic of Psychiatry, Mersin Sehir Egitim ve Arastirma Hastanesi, Toroslar, Mersin, Turkey.
Medicine
|March 11, 2025
概括
神经乱性恶性综合征 (NMS) 是抗精神病药物的罕见但严重并发症. 这项案例研究强调了在接受长效注射帕利皮里治疗的患者中的NMS,强调了临床警的必要性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 神经乱性恶性综合征 (NMS) 是神经乱性药物的关键性,可能致命的不良反应.
- 帕利佩里是一种非典型的抗精神病药物,用于治疗精神分裂症.
- 关于长效注射抗精神病药物 (LAI) 的NMS发病率的数据有限,需要进一步的案例研究.
研究的目的:
- 在接受LAI paliperidone的患者中报告NMS病例.
- 为了解与LAI非典型抗精神病药物相关的NMS做出贡献.
主要方法:
- 一名63岁的男性患有精神分裂症,发烧,肌肉硬,意识变化在LAI paliperidone启动后2天.
- 临床检查显示发烧 (39.5°C),震,刚性,困惑和肌酸激酶升高 (1895 U/L).
- 通过临床表现和实验室发现,NMS的诊断得到了证实.
主要成果:
- 患者接受了烯和阿米苏尔普里德治疗13天.
- 观察到妄的显著改善和生命体征的稳定.
- 实验室标记正常化,患者在14天后出院.
结论:
- 尼姆斯是一种罕见但危急的紧急情况,与抗精神病药物使用有关,包括非典型药物如帕利佩里.
- 临床医生必须在服用非典型抗精神病药物,特别是LAI配方的患者中保持对NMS的高度怀疑指数.
- 及时识别和治疗对于管理NMS和预防死亡至关重要.
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