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全免疫炎症值和全身炎症指数作为牛皮患者全身炎症的衡量标准:一项回顾性研究

Seyma Basar Kilic¹, Huseyin Erdal²

¹Department of Dermatology and Venereology, Faculty of Medicine, Aksaray University, Aksaray, Turkey.

|March 11, 2025

概括

系统性免疫炎症指数 (SII) 和泛免疫炎症值 (PIV) 可以作为牛皮的预后标志物. 这些炎症标志物与全身炎症反应指数 (SIRI) 一起显示出评估牛皮严重程度和活动的潜力.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
生物统计学生物统计学

背景情况:

牛皮是一种慢性,免疫媒介疾病,具有全身炎症.
中性细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),全身免疫炎症指数 (SII),全身炎症反应指数 (SIRI) 和泛免疫炎症值 (PIV) 是公认的炎症指标.

研究的目的:

在患有牛皮的患者中研究NLR,PLR,SII,SIRI和PIV的联合实用性.
探索这些炎症标志物与牛皮严重程度之间的相关性,根据牛皮严重程度区域指数 (PASI) 进行评估.

主要方法:

追溯病例控制研究涉及71名牛皮患者和70名健康对照.
对NLR,PLR,SII,SIRI和PIV进行计算和分析.
统计分析用于比较群体并评估与PASI分数的相关性.

主要成果:

牛皮患者和对照人群中中性粒细胞,淋巴细胞,单细胞和血小板的统计学显著差异 (P < .05).
在SII和PASI分数之间发现了直接关系 (P = .004,r = 0.34).
在SII,PIV和PASI之间观察到正相关性 (P = .006,R = 0.32对于PIV). 预测牛皮的SII曲线下的面积为0.611,最佳切线为442.7.7.

结论:

在评估牛皮患者中,SII,SIRI和PIV显示出潜在的实用性.
SII和PIV可以作为牛皮的独立预后标志物.
PLR没有显示两组之间的统计学上显著差异.

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