Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

What is Monogastric Digestion?01:50

What is Monogastric Digestion?

70.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
Mismatch Repair01:20

Mismatch Repair

4.7K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.7K
Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Global forecasts of decubitus ulcer burden among older adults across sociodemographic settings to 2030.

Medicine·2026
Same author

Impact of hepatotoxicity and lipid metabolism-related toxicity on survival and quality of life in patients with high-volume metastatic hormone-sensitive prostate cancer treated with rezvilutamide in the CHART trial: a post hoc analysis.

BMC medicine·2026
Same author

The triglyceride glucose-body mass index and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.

Frontiers in nutrition·2026
Same author

Electron-rich dianion vacancies boost diazenide intermediates for efficient chemical looping ammonia synthesis.

Nature communications·2026
Same author

BTKi orelabrutinib improved the outcome of newly-diagnosed PCNS-LBCL by alleviating MyD88<sup>L265P</sup>-induced PIM1 stability.

Journal of hematology & oncology·2026
Same author

Electric polarization modulation through continuous phase regulation of the KNbO<sub>3</sub> nanocrystals at room temperature.

Nanoscale·2026

相关实验视频

Updated: May 23, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.2K

肠道微生物群和骨 necrosis:一个门德尔的随机化研究.

Yong Cai1, Chaoqing Zhou2, Junjie Guan2

  • 1Department of Orthopaedics, Xishui County People's Hospital, Across from Hongding Community, Zunyi City, Guizhou Province, China.

Medicine
|March 11, 2025
PubMed
概括

这项研究揭示了特定的肠道微生物与骨髓缩 (ON) 之间的因果关系,确定了与这种疾病相关的五种细菌种群. 这些发现为针对ON的新型微生物向疗法铺平了道路.

更多相关视频

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

610
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.7K

相关实验视频

Last Updated: May 23, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.2K
Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

610
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.7K

科学领域:

  • 微生物学 微生物学
  • 遗传学 是一个遗传学.
  • 骨疾病 骨疾病

背景情况:

  • 骨髓缩 (ON) 是一种衰弱的骨疾病,发病率越来越高.
  • 人们怀疑肠道微生物群在ON病变发生中的作用,但尚未确定其因果关系.
  • 了解肠骨轴对于开发有效的ON疗法至关重要.

研究的目的:

  • 通过使用孟德尔随机化来研究肠道微生物组成和骨 necrosis (ON) 之间的因果关系.
  • 确定特定的肠道微生物种群因果关系与发展ON的风险相关.
  • 探索肠道微生物群对ON的影响的遗传基础.

主要方法:

  • 孟德尔随机化 (MR) 分析利用了来自MiBioGen联盟和英国生物银行的数据.
  • 逆方差加权 (IVW) 方法用于评估微生物种类对ON的因果关系.
  • 敏感性分析 (例如,异质性,性) 和反向MR以确保发现的稳定性.
  • 单核酸多态 (SNP) 标注,以识别参与ON病变的宿主基因.

主要成果:

  • 五种肠道微生物种群表明,与ON有统计学上显著的因果关系.
  • 排序Erysipelotrichales,家族Erysipelotrichaceae和类Erysipelotrichia与增加的ON风险 (OR>1) 有关.
  • 克里斯森氏族R和家族XIII家族与降低的ON风险 (OR <1) 有关.
  • 反向MR证实ON对已识别的肠道类型没有因果作用.
  • SNP注释确定了20个宿主基因,可能会调解肠-ON关系.

结论:

  • 这项研究提供了强有力的证据,证明特定的肠道微生物群组成和骨髓缩之间存在因果关系.
  • 已识别的微生物种群代表了预防或治疗ON的潜在治疗点.
  • 这些发现加深了对肠骨轴及其对骨健康的影响的理解.