加拿大阿尔伯塔省间歇性肺部疾病的发病率,患病率和死亡率:基于人口的研究
Kerri A Johannson1, Zhaoyu Liu2, Danielle A Southern3,4
1University of Calgary, Medicine, Calgary, Alberta, Canada; kerri.johannson@ahs.ca.
Annals of the American Thoracic Society
|March 11, 2025
概括
这项研究发现,在加拿大阿尔伯塔省,间歇性肺病 (ILD) 患病率在十年内增加,死亡率下降. 这些发现表明,ILD的负担比以前报告的要高.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 成年间歇性肺病 (ILD) 的流行病学是不确定的,因为先前的研究估计异质.
- 基于人口的数据对于准确的ILD发病率,流行率和死亡率评估至关重要.
- 以前的研究可能低估了间歇性肺病的整体负担.
研究的目的:
- 在10年的时间内定义成人间歇性肺病 (ILD) 的发病率,流行率和死亡率.
- 利用基于人口的行政数据进行强有力的ILD流行病学分析.
- 使用经过验证的性能特征,为ILD建立可靠的案例定义.
主要方法:
- 在加拿大阿尔伯塔省 (2010-2019) 创建了一个行政ILD队列,使用住院,门诊和医生计费数据.
- 从已确立的ILD队列中得到验证的病例定义被应用到一般人群中,通过嵌套病例控制设计进行性能测试.
- 根据年龄和性别标准化的发病率和流行率计算出每10万名有风险的成年人和总人口;Cox模型评估了死亡风险.
主要成果:
- 在2010年至2019年期间,确定了31,492个事件和42,549个流行成人ILD病例,准确度很高 (敏感度96.8%,特异性98.5%).
- 平均年龄标准化的ILD发病率为107.9/100,000名风险成年人,而点患病率从2010年的416.5/100,000增加到2019年的789.7/100,000.
- 在ILD患者的一年全因死亡率从14.5% (2011) 降至11.7% (2018),在异形性肺纤维化 (IPF) 中也有类似的改善.
结论:
- 从已建立的队列中获得的基于索赔的案例定义对于开发行政ILD队列是有效的.
- 在研究期间,ILD发病率保持稳定,患病率增加,死亡率下降.
- 较高的ILD发病率和患病率估计表明,在以前的报告中大幅低估了ILD的发生率和患病率,突出显示疾病负担增加.
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