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Updated: May 23, 2025

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
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脂质-siRNA组织调节脂质纳米颗粒的细胞内动力学

Yulin Mo1,2, Alexander F A Keszei2, Shagun Kothari3

  • 1Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

Journal of the American Chemical Society
|March 11, 2025
PubMed
概括

脂质纳米粒子 (LNP) 结构影响siRNA传递. 优化脂质-siRNA组织可以增强RNA治疗的细胞吸收和内体逃生.

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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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