在临床实践环境中,增殖性糖尿病视网膜病变的视觉结果和坚持挑战与抗VEGF单一治疗
Jay R Maturi1, Nick Boucher2, Rusirini Fernando2
1Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Retina (Philadelphia, Pa.)
|March 11, 2025
概括
扩散性糖尿病视网膜病变 (PDR) 的治疗坚持影响结果. 抗VEGF治疗中的差距增加了视力损失和并发症的风险,突出了维持PDR治疗计划的挑战.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 糖尿病视网膜病变 糖尿病视网膜病变
背景情况:
- 扩散性糖尿病视网膜病变 (PDR) 需要持续治疗以防止视力丧失.
- 糖尿病视网膜病变临床研究网络 (DRCR) 的S协议提供了PDR的治疗指南.
研究的目的:
- 评估DRCR协议S之外的PDR的真实世界抗VEGF治疗模式.
- 评估与PDR治疗变异相关的长期眼部并发症.
主要方法:
- 对26632个未经治疗的眼睛进行了回顾性队列研究,这些眼睛接受了抗VEGF注射 (2016-2021年).
- 评估与S协议 (4周内4次注射) 的一致性和6个月的治疗间隔.
- 多变量后勤回归分析了结果.
主要成果:
- 与S协议一致的眼睛在两年内比非一致的眼睛 (-0.6个字母) 显示出更好的视力敏度增长 (+3.0个字母).
- 超过40%的患者在一年内失去了随访.
- 显著的治疗差距与更高的玻璃切除术,视网膜脱落和新血管玻璃瘤相关.
结论:
- 在临床实践中,维持PDR的强化抗VEGF计划是具有挑战性的.
- 治疗不坚持与视力不良结果和严重眼部并发症风险增加有关.
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