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Updated: May 23, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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具有混合KOR/MOR活动的元替代N-cyclopropylmethyl-nornepenthones的结构-活性关系分析

Siyuan Tang1, Shuyang Hu2, Lijing Feng3

  • 1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai, 201203, China; School of Physical Science and Technology, ShanghaiTech University, No. 393 Huaxiazhong Road, Shanghai, 201210, China.

European journal of medicinal chemistry
|March 11, 2025
PubMed
概括

新的双作用卡帕阿片类受体 (KOR) 和阿片类受体 (MOR) 调节器在治疗物质使用障碍 (SUD) 方面表现有前途. 化合物10a在临床前模型中有效地阻断了吗啡的影响,提供了潜在的新治疗途径.

关键词:
这是一种 KOR 激动剂.这是一种MOR抗剂.N-环甲基 - 诺内芬子结构与活动的关系.药物使用障碍物使用障碍物

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