相关实验视频

Updated: May 23, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

采用T细胞免疫疗法的表观遗传增强

Zhenyu Dai¹, Melody Smith¹

¹Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

|March 11, 2025

概括

抑制肠道同类素1 (EZH1) 和EZH2的增强剂使瘤对CAR/TCR疗法更敏感. 在临床前模型中,这种方法通过增强瘤免疫性和T细胞功能来改善癌症免疫疗法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

基于化学抗原受体 (CAR) 和T细胞受体 (TCR) 的疗法对癌症治疗具有前景.
瘤微环境可以限制采用细胞疗法的疗效.
增强质同源1 (EZH1) 和EZH2是参与瘤进展的表观遗传调节剂.

研究的目的:

研究抑制EZH1和EZH2的潜力,以增强基于CAR/TCR的癌症疗法.
评估EZH1/EZH2抑制对瘤免疫性和T细胞功能的影响.
评估EZH1/EZH2联合抑制和CAR/TCR治疗在临床前癌症模型中的疗效.

主要方法:

使用血液和固体癌症的小鼠模型进行临床前研究.
使用基于CAR/TCR的疗法与EZH1/EZH2抑制剂结合使用.
对瘤免疫性,T细胞表型和整体治疗反应的分析.

主要成果:

抑制EZH1和EZH2显著提高了基于CAR/TCR的疗法的疗效.
联合治疗重新编程瘤,使它们更具免疫性,更容易接受T细胞的攻击.
在各种癌症类型的临床前模型中观察到改善的T细胞表型和功能.

结论:

将EZH1/EZH2抑制与CAR/TCR疗法结合起来,是克服治疗耐药性的有希望的策略.
这种方法具有治疗血液和固体瘤的潜力.
目前正在进行临床试验,以进一步评估人类患者的安全性和治疗益处.

更多相关视频

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Cell-mediated Immune Responses

Cell-mediated Immune Responses