在患有急性心力衰竭的老年人中,日常血压变化和认知功能
Michiaki Nagai1,2, Keigo Dote2, Masaya Kato2
1Cardiovascular section, Department of medicine, University of Oklahoma Health Science Center, Oklahoma, USA.
American journal of hypertension
|March 11, 2025
概括
患有急性不补偿性心力衰竭的老年人中高血压的变化与认知障碍有关,特别是在心力衰竭中,保留喷射小部分患者.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 心力衰竭 (HF) 和认知障碍经常在老年人中并存.
- 虽然先前的研究表明血压变化 (BPV) 与认知能力下降之间存在联系,但高血压的具体机制尚不清楚.
- 这项研究调查了BPV和认知障碍在患有急性不补偿性心力衰竭 (ADHF) 的老年患者之间的关联.
研究的目的:
- 为了评估高血压变性 (BPV) 与ADHF老年患者的认知障碍相关的假设.
- 探索BPV和认知功能的不同测量之间的关系.
- 为了确定这种关联是否在心力衰竭表型中存在差异.
主要方法:
- 在245名患有ADHF的老年患者中,使用迷你精神状态检查 (MMSE) 评估了日常住院血压变化 (BPV) 和认知功能.
- 使用标准偏差 (SD),变化系数 (CV),最大BP,最小BP和范围 (δ) 在7天内测量BPV.
- 采用后勤回归分析,调整了混因素,并根据HF表型进行了分层分析.
主要成果:
- 在MMSE得分四分位数中观察到透气血压 (DBP) 变化 (SD,CV,δ) 的显著差异.
- 经过对混因子进行调整后,较高的DBP变异性 (SD,CV,最大,δ) 与较低的MMSE得分有显著的关联.
- 日复一日的DBP变化和较低的认知功能之间的关联在心力衰竭患者中特别明显,心力衰竭患者具有保存的射出分数 (HFpEF).
结论:
- 在患有ADHF的老年患者中,认知障碍越来越普遍.
- 日常血压变化与这一群体的认知障碍有显著的关联.
- 这种关联在心力衰竭患者中特别明显,心力衰竭患者具有保存的喷射分数 (HFpEF).
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