成年长期冠状病毒疾病2019年:定义,流行病理生理学和临床表现
Ivette Emery1, Clifford Rosen2
1Center for Clinical and Translational Science, MaineHealth Institute for Research, Scarborough, ME, USA.
长期COVID-19在感染SARS-CoV-2后影响10人中的1人,呈现为复杂的多系统性疾病. 研究探讨了各种原因,包括病毒持久性和自身免疫性,以及已识别的风险因素,如女性性别和严重疾病.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 长型冠状病毒病2019 (COVID-19) 是SARS-CoV-2感染后的一个复杂的多系统状况.
- 大约10%的患有严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的人患有长期COVID-19.
- 长期COVID-19的病因仍然是多因素的,除了初始病毒暴露之外没有发现单一的原因.
研究的目的:
- 总结我们目前对长期COVID-19的理解.
- 探索潜在的病理生理机制.
- 确定与长期COVID-19发展相关的风险因素.
主要方法:
- 审查关于长期COVID-19的现有文献.
- 对拟议的病理生理学理论 (病毒持久性,自身免疫,免疫衰竭) 的分析.
- 流行病学风险因素的识别和总结.
主要成果:
- 长期COVID-19的特点是不同的症状和持续时间.
- 存在多种病因理论,包括病毒持久性,免疫失调和自身免疫.
- 确定的危险因素包括女性性别,严重或住院的急性COVID-19,之前的SARS-CoV-2感染,以及缺乏疫苗接种.
结论:
- 长期COVID-19是SARS-CoV-2的一个显著的后传染性后续.
- 了解病理生理学对于开发有效治疗方法至关重要.
- 识别风险因素有助于预测和潜在地预防长期COVID-19.
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