罗苏瓦斯塔丁和酸盐在甲状腺切除术后预防声音变化的影响:一项随机对照试验
Mehdi Ghasemian1, Mehrdad Karajizadeh1, Mohammad Reza Yousefi1
1Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Journal of voice : official journal of the Voice Foundation
|March 11, 2025
概括
这项研究发现,罗斯瓦斯塔丁和酸醇在甲状腺切除术后并没有显著地防止语音变化. 在服用药物和不服用药物组之间没有观察到语音障碍严重程度的差异.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 甲状腺切除术是甲状腺病变的常见手术.
- 声音变化是频繁发生的不良影响,影响甲状腺切除术后患者的幸福感.
- 目前对减轻这种副作用的药理干预措施的研究是有限的.
研究的目的:
- 为了研究罗斯瓦斯塔丁和酸盐在全甲状腺切除术后预防语音变化的有效性.
- 为了比较接受罗斯瓦斯塔丁,罗斯瓦斯塔丁加卡尔西醇的患者的语音结果,与没有药物.
主要方法:
- 一项并行,单盲,区块随机对照试验与177名接受全甲状腺切除术的成年患者进行.
- 患者被分配给接受罗斯瓦斯塔丁,罗斯瓦斯塔丁和,或没有药物,从手术前14天开始.
- 手术后两周,使用客观和主观措施评估了声音的变化.
主要成果:
- 在这三个组中,声音变化的严重程度没有显著差异 (P > 0.05).
- 报告了最小的,中度的和严重的语音障碍的发生率.
- 当将药物组与对照组进行比较时,没有发现显著差异.
结论:
- 无论是罗斯瓦斯塔丁,还是罗斯瓦斯塔丁与酸的组合,都没有在预防甲状腺切除术后的语音变化方面显著的益处.
- 该研究表明,在治疗和未治疗患者之间,语音变化严重程度或语音障碍指数组件没有差异.
- 需要进一步的研究来确定有效的策略来改善甲状腺切除术后患者的治疗结果和生活质量.
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