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Updated: May 23, 2025

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通过临床药物和胆固醇对人类GlyT1的调节

Na Li1, Yiqing Wei2,3, Renjie Li2,3

  • 1Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Nature communications
|March 12, 2025
PubMed
概括

这项研究揭示了甘氨酸载体1 (GlyT1) 功能和抑制的结构基础. 胆固醇结合对GlyT1构造变化至关重要,影响谷氨酸信号传递和潜在的精神分裂症治疗.

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