与药物相关的牙疾病:使用不成比例分析进行回顾性药监测评估
Kannan Sridharan1, Gowri Sivaramakrishnan2
1Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain. skannandr@gmail.com.
BDJ open
|March 12, 2025
概括
这项研究使用美国FDA不良事件报告系统确定了与牙疾病的显著药物关联. 关键发现将抗骨质疏松剂和抗血栓剂等药物与各种牙疾病联系起来,强调需要提高认识.
科学领域:
- 药物监督 药物监督 药物监督
- 口腔医学是指口腔医学.
- 药品安全 药品安全
背景情况:
- 与药物相关的牙疾病对口腔健康构成重大威胁.
- 美国食品和药物管理局不良事件报告系统 (USFDA AERS) 数据库是识别与药物有关的不良事件的宝贵资源.
研究的目的:
- 综合评估特定药物与牙疾病之间的关联.
- 利用USFDA AERS数据库用于药物诱导的牙疾病信号检测.
主要方法:
- 美国FDA AERS (2004-2024) 的数据挖掘,用于八种牙疾病的首选术语.
- 应用频率主义和贝叶斯不成比例分析来识别潜在的药物相关信号.
- 生成火山图片以可视化和按统计学意义排列药物障碍的关联.
主要成果:
- 对11,465份报告的分析显示,多种药物类别与牙疾病之间存在显著的关联.
- 抗骨质疏松症药物,抗血栓剂,通道阻断剂和免疫抑制剂经常受到影响.
- 特定的药物,如芬伊托因,牙科制剂,费纳斯特,COVID-19疫苗,和levothyroxine显示显著的关联与牙问题,如缩,出血,和变色.
结论:
- 医疗保健提供者需要提高对与药物相关的潜在口服副作用的认识.
- 对药物诱导的牙疾病机制的进一步研究至关重要.
- 制定跨学科的管理策略对于改善长期药物治疗患者的口腔健康结果至关重要.
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