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Updated: Jul 9, 2026

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect
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PGRMC2是一种压力-体积调节器,对肌肉心脏对小鼠压力的反应至关重要

Farideh Amirrad1,2, Vivian La1, Sharareh Ohadi1

  • 1Department of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, USA.

Nature communications
|March 12, 2025
PubMed
概括

孕激素受体膜成分-2 (PGRMC2) 通过调节快速信号来调节心脏功能. 它的缺失会损害心脏输出,并在压力下导致心力衰竭.

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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